Mass Spectrometry Innovator Bruker Releases Groundbreaking New Products to Market

Drug Enforcement Tech

Posted by AI on 2025-09-01 05:00:20 | Last Updated by AI on 2025-09-05 00:15:59

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subtitle: The new benchtop metabolomics and lipidomics mass spectrometer is a powerful tool for environmental analysis, toxicology, and drug testing

Introduction:

At this years American Society for Mass Spectrometry (ASMS) conference in Baltimore, Bruker launched two new groundbreaking products: the timsMetabo mass spectrometer and new applications for its DART-MS technology. Senior Vice-President of Bruker Applied Mass Spectrometry Jeffrey Zonderman gave us an exclusive interview about these new releases and how they will affect the industry.

Body Paragraphs

TimsMetabo mass spectrometer:

- The timsMetabo is a benchtop mass spectrometer designed for four-dimensional (4D)-metabolomics and 4D-lipidomics.

- Its specialty is in achieving exceptional sensitivity through trapped ion mobility spectrometry (TIMS) technology.

- It was developed further through a novel scan mode called Mobility Range Enhancement (MoRE) and a new high-precision quadrupole and Brukers Athena Ion Processor (AIP).

New advancements for DART-MS technology:

- Integration of RECIPE Chemicals + Instruments ClinMass for LCMS

- Future introduction of the ClinDART assay kits both of which will run on Brukers EVOQ DART-TQ+ system

What these mean for applications such as therapeutic drug monitoring, drugs of abuse analysis, and environmental analysis:

Zonderman commented that these innovations will open doors for sectors to use TIMS tools, benefiting areas such as wastewater analysis and per- and polyfluoroalkyl substances (PFAS) analysis.

He highlighted how the timsMetabo will allow people to deepen research on developing assays for such challenges and how TIMS can help with complex experiments involving thousands of PFAS analogs concerning contaminants in wastewater or PFAS contamination in soil.

For toxicology and therapeutic drug monitoring, he emphasized the challenges of analyzing drugs of abuse, citing difficulties in identifying substances due to the myriad of novel psychoactive substances (NPS) and isomers.

He concluded by stating that the new timsMetabo will be perfect for separating things out based on their ion mobility characteristics, allowing the detection of very low-level drugs and their metabolites and helping to isolate and identify new entities on the drug market.

Looking to the future, he foresees a time where chromatography-free MS will be the norm, saying that he "sees that chromatography-free mass spectrometry is going to be the way to go... [and is] the more sustainable area to focus on."

Conclusion

These new products from Bruker are game-changers for environmental analysis, toxicology, and drug testing, with the timsMetabo offering enhanced sensitivity and new applications for DART-MS technology.

Zonderman highlighted how these will help take TIMS from being a proteomics tool to becoming more widely used in metabolomics, environmental analysis, and his area of contaminant analysis.

He concluded by saying that chromatography-free MS is the future direction, making mass spectrometry more accessible and sustainable.

This year at ASMS, Brukers customers and collaborators were able to prove the efficacy of these new innovations, with many presenting on the implementation of these developments.

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